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Bectumomab (CAT#: TAB-047-F(E))

Datasheet
DESCRIPTION CATALOG # SIZE PRICE
Anti-Human CD22 Recombinant Antibody Fab Fragment(LymphoScan) TAB-047-F(E) 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant monoclonal antibody fragment Fab to CD22. Bectumomab (marketed under the trade name LymphoScan) is a mouse monoclonal antibody labelled with the radioactive isotope technetium-99m. It is used to detect non-Hodgkin's lymphoma.
  • Target
  • CD22
  • Type
  • Fab' - G2a - kappa
  • Immunogen
  • A combination of recombinant human CD22 extracellular 25 domain and CHO ceIls engineered to express full-length human CD22 on the ceIl surface
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in ELISA, FC, IP, FuncS, IF, Neut, WB and most other immunological methods.
  • CAS
  • 158318-63-9
  • Trade name
  • lymphoscan
  • Specific Activity
  • Tested positive against native human antigen.
  • Protein Construction
  • Immunoglobulin G2a,anti-(human CD22 (antigen))Fab fragment (mouse monoclonal IMMU-LL2 g2a-chain), disulfide with mousemonoclonal IMMU-LL2 light chain
  • Predicted N terminal
  • H chain: EVQLVQS; L chain: EIVLTQS
  • Purity
  • Purity >95% by SDS-PAGE.
  • Size
  • 1mg
  • Storage
  • Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.

BACKGROUND

  • Antigen Description
  • CD22 or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signalling.
  • Function
  • protein binding; sugar binding;
  • Synonyms
  • CD22; CD22 molecule; CD22 antigen; B-cell receptor CD22; sialic acid binding Ig like lectin 2; SIGLEC 2; SIGLEC2; BL-CAM; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2; SIGLEC-2; FLJ22814; MGC130020;

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